The out-of-the-box comfort was impressive. The Vomero 17's blend of plush ZoomX foam underfoot and a more stable React foam base provided a well-cushioned yet supportive ride. Even on Rome's notorious ancient cobblestones in Trastevere, which have historically punished my feet by mid-afternoon, the Vomeros kept me comfortable for a solid 8 hours of exploration. By hour four navigating the seemingly endless marble floors of the Vatican Museums, my feet were still feeling good – a noticeable improvement over firmer shoes I’ve worn on similar museum marathon days. The fit is secure, with a well-padded heel and a midfoot that cinches down nicely. I wear a standard D width and found them accommodating, but it’s a significant plus that Nike offers wide (2E) and even extra-wide (4E) options, because foot swelling on long travel days is a real factor for many. As u/Fearless-Target-913 mentioned on Reddit, they found the Vomero 17 "to be the most comfortable," and my in-depth city test supports this, especially for travelers with medium to high arches. They run true to size for most, but trying them on is always best if you have very flat feet or use bulky orthotics.